immunis · type I hypersensitivity

The anaphylaxis scope

A live mechanistic model of the IgE / mast-cell cascade. Move the controls and watch mediators, blood pressure, and airway respond — then find the moment epinephrine stops working.
integrating · rk4

Hemodynamics & airway

Mean arterial pressure and airway resistance over 60 min
MAP (mmHg) airway resistance shock threshold 65 epinephrine antihistamine
Severity
—
MAP nadir
—mmHg
Airway peak
—×base
Peak HR
—bpm

Mediator kinetics

Why the lab test is tryptase, not histamine
histamine · t1/2~2 min tryptase · t1/2~2 h PAF · severity driver
reading

Scenario console

How heavily mast cells are pre-loaded with allergen-specific IgE. Higher = more explosive degranulation.
Amount of allergen re-encountered on exposure.
The only first-line treatment. Time from exposure to injection — drag it right to watch the rescue window close.
Treats hives and itch only — blocks histamine, not the leukotrienes or PAF driving airway and shock.
The enzyme that clears PAF. Genetically low activity is linked to fatal reactions.