immunis · IPEX syndrome

One failing node, two diseases

IPEX is the natural experiment: lose functional regulatory T cells and you get severe autoimmunity AND severe allergy at once. Turn the single Treg dial and watch both arms move together — then find the therapy that fixes both.
coupled model

Shared node · regulatory (Treg) fitness

The FOXP3 / Treg tolerance set-point — the one variable both diseases depend on
0.50
◀ IPEX (no Tregs)healthy tolerance ▶
Autoimmune arm
Autoreactive effectors escape → tissue destroyed
—% lost
course
—
Allergic arm
Unchecked Th2/IgE → sensitization → anaphylaxis risk
—sensitized
allergen challenge
—
⇄

Co-escalation across the IPEX axis

Both burdens as a function of the shared Treg node — they rise together
autoimmune tissue damage allergic sensitization current Treg fitness
Genetic risk feeding the autoimmune arm.
Environmental allergen exposure feeding the allergic arm.

Intervention

Only the shared-node therapy fixes both arms. Arm-specific therapies leave the other disease untouched.
the bridge