immunis · autoimmune disease

The tolerance monitor

Self-tolerance is a tug-of-war between autoreactive effector cells and regulatory T cells. Tip the balance and watch the same immune system produce health, a single flare, relapsing-remitting disease, or relentless progression — then treat it.
2-year course

Disease course

Effector vs regulatory balance and cumulative tissue damage over 24 months
autoreactive effector regulatory (Treg) tissue damage (%) autoantibody
Clinical course
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Tissue lost
—%
Relapses
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Autoantibody
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reading

Immune balance

Treg strength — the tolerance set-point. The single most decisive dial: high holds tolerance, low lets autoimmunity escape.
Permissive genetic background (HLA, risk loci) scaling how readily effectors activate.
Precipitants (infections, stress) every N days. On a susceptible-but-not-progressive background they produce relapsing-remitting disease.

Therapy

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Antigen removal models the celiac gluten-free diet — it only works when the driving antigen is dietary, not endogenous.